In the process of drug production, it is often the most important link to poison the air germicide in the GMP workshop. The traditional methods are ultraviolet disinfection, ozone disinfection, formaldehyde fumigation, Novo fumigation, etc. Most pharmaceutical enterprises have problems mainly due to incomplete disinfection or secondary pollution, Therefore, if it can be used in places with low requirements such as transfer windows, ozone or ultraviolet disinfection can achieve the effect. The Disinfection Technical Specifications describes in detail that the surface and air of objects immersed in ozone gas can be killed by bacteria on the surface and in the air after a period of contact. However, spores cannot be completely killed.

Application of Ultraviolet in GMP

Ultraviolet ray sterilizes by light wave radiation. The light wave travels in a straight line. Its radiation intensity is inversely proportional to the square of the distance. Only the position where it is exposed and reaches the radiation standard can have the sterilization effect. And the bactericidal ability of all ultraviolet rays decreases with the increase of use time. The main problems of ultraviolet sterilization are: its penetration capacity is small, and the disinfection effect is not good in places where ultraviolet radiation cannot reach; Its anti-virus ability decreases with the increase of service time, and the lamp life is short, the replacement is too frequent, and the operation cost is high.

Application of ozone in GMP

Ozone sterilization has a strong taste and cannot be discharged naturally. It requires air conditioner to replace fresh air for a long time, thus increasing energy consumption. At the same time, there is also the problem of secondary pollution. The fumigation time is long and there are secondary pollutants, which are harmful to human health.

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