In the process of drug production, it is often necessary to control the most important aspect of air sterilization in GMP workshops. Traditional methods such as ultraviolet disinfection, ozone disinfection, formaldehyde fumigation, and Novofel fumigation are used. Most pharmaceutical companies have problems such as incomplete disinfection or secondary pollution, So if used in low demand situations such as transfer windows, ozone or ultraviolet disinfection can achieve the desired effect. The “Disinfection Technical Specifications” provide detailed information that for surfaces and spaces immersed in ozone gas, contact for a period of time can kill surface bacteria and bacteria in the air. However, spores cannot be completely killed.

Application of Ultraviolet in GMP

Ultraviolet radiation kills bacteria through the action of light waves, which propagate in a straight line. Its intensity is inversely proportional to the square of the distance, and only when it reaches the location and meets the irradiation standard can it have a bactericidal effect. And the bactericidal ability of all ultraviolet rays decreases with increasing usage time. The main problem with ultraviolet sterilization is that it has low penetration ability and poor disinfection effect in areas where ultraviolet radiation cannot reach; Its antivirus ability decreases with the increase of usage time, and the lamp tube has a short lifespan, frequent replacement, and high operating costs.

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